Circulating re-entrant waves promote maturation of hiPSC-derived cardiomyocytes in self-organized tissue ring
J. Li, L. Zhang, L. Yu, I. Minami, S. Miyagawa, M. Hörning, J. Dong, J. Qiao, X. Qu, Y. Hua, Fujimoto, Y. Shiba, Y. Zhao, F. Tang, S. Miyagawa, Y. Chen, Y. Sawa, C. Tang, L. Liu
Communications Biology, 3, 122, 2020
Brief Summary: ''HiPSC-derived cardiomyocytes can form three-dimensional self-organized tissue rings. The trained tissue showed matured features including structural organization, increased cardiac-specific gene expression, enhanced Ca2+-handling properties, an increased oxygen-consumption rate, and enhanced contractile force. A mathematical model interprets the origination, propagation, and long-term behavior of the findings.''