Optical Ultrastructure of Large Mammalian Hearts recovers Discordant Alternans by in-silco Data Assimilation
A. Loppini, J. Erhardt, F.H. Fenton, S. Filippi, M. Hörning* and A. Gizzi
Frontiers in Networt Physiology (accepted for publication)
Brief Summary: ''... Here we apply Fourier transformation imaging (FFI) to whole-ventricle fluorescence observations. We identify complex spatial patterns of voltage alternans and characterize higher-order rhythms. We integrate the optical ultrastructure obtained by FFI analysis within a fine-tuned electrophysiological mathematical model of the cardiac action potential. We build up a novel data assimilation procedure demonstrating its reliability in reproducing complex alternans patterns in two-dimensional computational domains. ...''