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Institute of Biomaterials and Biomolecular Systems

The Institute of Biomaterials and Biomolecular Systems (IBBS) consists of the department of Biobased Materials, Biophysics, Intelligent Biointegrative Systems, Neurobiology, and Plant Biotechnology.

Managing director: Prof. Ingrid Ehrlich and Prof. Michael Heymann

Head of departments:

Prof. Ingrid Ehrlich	Neurobiology
Prof. Arnd Heyer	Plant Biotechnology
Prof. Michael Heymann	Integlligent Biointegrative Systems
Prof. Stephan Nussberger	Biophysics
Prof. Ingrid M. Weiss	Biobased Materials
Prof. Amirreza Aghakhani	Microrobotic Biomedical Systems

Research Units & Guests:

apl. Prof. Dr. Wolfgang Hauber	Systems Neurobiology
apl. Prof. Dr. Christina Wege	Molecular and Synthetic Plant Virology
apl. Prof. Dr. Franz Brümmer	Aquatic Biodiversity and Scientific Diving
Prof. i.R. Robin Ghosh	Biophysics

News

April 2020

Schöpfer et al. 2020, Frontiers in Environmental Science

News
4/23/20

September 2019

Hörning and Shibata, Biophysical Journal 116 (2019)

News
9/5/19

May 2019

Umeshima et al., Neuroscience Research, 2019

News
5/13/19

Li et al., Communications Biology, 2020

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5/13/19

October 2019

Hörning et al., J. of Structural Biology, 2020

News
10/21/19

September 2020

We are looking for a PhD Student (m/f/d)

News
9/8/20

October 2019

Hörning et al., J. of Structural Biology, 2020

News
10/21/19

August 2021

Hörning et al., Frontiers Cell and Developmental Biology (2021)

News
8/24/21

March 2022

Loppini et al., Frontiers in Network Physiology (2022)

News
3/7/22

June 2022

Daul et al., 2022, Galvanotaxis of ciliates

News
6/10/22

July 2022

Brock et al., 2022, Mechanosensitive Cross-Talk between Matrix Stiffness and Protein Density

News
7/5/22

August 2022

Holzwarth et al. (2022) Modulating chitin synthesis in marine algae

News
8/23/22

Holzwarth et al. (2022) Modulating chitin synthesis in marine algae

News
8/23/22

Holzwarth et al. (2022) Modulating chitin synthesis in marine algae

News
8/23/22

October 2023

Dörr et al., 2023 ''Functional Materials and Principles in Ciliates''

News
10/10/23

March 2024

Erisis et al., 2024 ''Self-organization of PIP3 waves is controlled by the topology and curvature of cell membranes.''

News
3/25/24

Erisis et al., 2024 ''Self-organization of PIP3 waves is controlled by the topology and curvature of cell membranes.''

News
3/25/24

August 2017

Cryo-EM Structure of TOM, Bausewein et al (2017) Cell 170: 693-700

News
8/15/17

May 2022

Bachelor- and Master-Projects (Nussberger Lab)

News
5/30/22

March 2018

New research proposal funded by the BW-Foundation (Nussberger Lab)

News
3/15/18

February 2019

The adoption of three-dimensional additive manufacturing from biomedical material design to 3D organ printing: Review, coauthored by Shuo Wang; Appl. Sci. (2019)

News
2/26/19

July 2018

Methoxyestradiol affects mitochondrial biogenesis in osteosarcoma cancer cells, Gorska et al. Cancer Gen. Proteom. 15: 73-89 (2018)

News
7/27/18

June 2019

Cryo-EM structure of Neurospora crassa respiratory complex IV: Bausewein et al. (2019) IUCrJ 6: 773-780, coauthored by S. Nussberger / Biophysics group

News
6/27/19

July 2019

The Art of Sucking Protein-Spaghetti presented at the 69th Lindau Nobel Laureate Meeting

News
7/5/19

September 2019

Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery. Biomaterials. 219: 119394 (2019), coauthored by Shuo Wang / Biophysics Group

News
9/16/19

Nitric oxide and its derivatives in the cancer battlefield: Kamm et al. (2019) Nitric Oxide: S1089-8603 (19) 30119-3.

News
9/16/19

March 2020

The structure of the TOM core complex in the mitochondrial outer membrane. Bausewein et al. (2020) Biological Chemistry

News
3/4/20

April 2018

Introduction into Biophysics - First video podcasts online for students of Technical Biology and Biomedical Engineering

News
4/16/18

October 2020

In depth interrogation of protein thermal unfolding data with MoltenProt. Kotov et al. (2020) Protein Science doi: 10.1002/pro.3986

News
10/31/20

December 2020

Regulation of mitochondrial dynamics in 2-methoxyestradiol-mediated osteosarcoma cell death. Magdalena Gorska-Ponikowska et al. (2021) Scientific Reports, 1-12

News
12/28/20

May 2022

Spatiotemporal stop-and-go dynamics of the mitochondrial TOM core complex correlates with three-state channel activity. Shuo Wang et al. Communications Biology: 5, 1-11 (2022)

News
5/17/22

Shuo Wang et al. exploit single-molecule measurements to uncover a potentially new mechanosensitive functionality of TOM. Blog post: Nature Portfolio Bioengineering Community (2022)

News
5/17/22

July 2022

Induction of 2-hydroxycatechol-estrogens O-methylation: A missing puzzle piece in diagnostics and treatment of lung cancer. Musial et al. Redox Biol. 55: 1-13 (2022)

News
7/8/22

Electron microscopy-based structure of TOM core complex now also published in the textbook Voet & Voet Biochemistry 4th edition - International adaptation (2021)

News
7/8/21

September 2022

Biophysics Group new member of the BMBF Cluster 4 Future initiative "nanodiag BW"

News
9/19/22

January 2023

Single-molecule imaging of lateral mobility and ion channel activity in lipid bilayers using TIRF microscopy. Wang et al. JoVE 192: 1-21, doi 10.3791/64970 (2023)

News
1/11/23

August 2023

Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Ornelas et al. PNAS 120: e2301447120 (2023)

News
8/15/23

July 2023

PhD lecture by Shuo Wang, Monday July 31, 10 am, room 9.120

News
7/17/23

April 2023

Biophysics Group: Open PhD position in single-molecule biochemistry / microscopy

News
4/3/23

March 2024

Tracking the activity and position of mitochondrial beta-barrel proteins. Shuo Wang et al. Methods Mol. Biol. 2778: 221-236 (2024)

News
3/14/24

May 2023

ICP and Biophysics group in RESEARCH and LIFE 04/23: The use of nanopores to detect potential diseases

News
5/1/23

JoVE Video: Single-molecule imaging of lateral mobility and ion channel activity

News
5/24/23

August 2023

TOM holo compex cryoEM structure on PNAS cover

News
8/20/23

March 2024

TOM core complex cryoEM structure on the cover of Springer Protocols / Methods in Molecular Biology

News
3/15/24

April 2024

New insights into the structure and dynamics of the TOM complex in mitochondria. Nussberger et al. Biochem. Soc. Trans. 52:911-922 (2024)

News
4/3/24

Single-molecule imaging of TOM activity on Biochemical Society Transactions cover

News
4/25/24

August 2024

3D DNA origami pincers that multitask on giant unilamellar vesicles. Zhan et al. Science Advances 10: eadn8903 (2024)

News
8/30/24

May 2023

Prediction of Por39 membrane porin loops of R. rubrum suitable for CoV2 epitope surface display. Markthaler et al. Comp. Struct. Biotech. J. (2023)

News
5/1/23

November 2024

Morphology remodeling and membrane channel formation in synthetic cells via reconfigurable DNA nanorafts. Fan et al. Nature Materials 24: 278-286 (2025)

News
11/5/24

May 2023

TOM and VDAC in Ionera's channel zoo

News
5/1/23

Pore proteins: about holes in mitochondria, Nussberger labor&more 1.10: 30-33 (2010)

News
5/1/16

March 2011

New third-party funded project (Nussberger Lab): De novo design of biological nanopores for biosensors

News
3/15/11

January 2025

Is TOM sensitive to mechanical cues? See review by Nussberger et al. in Adv. Exp. Med. Biol. pp. 1–28, in press (2025)

News
1/8/25

Reconstitution of the membrane protein OmpF into biomimetic block copolymer-phospholipid hybrid membranes. Bieligmeyer et al. Beilstein J. Nanotechnol. 7: 881-892 (2016)

News
1/8/16

May 2025

Translational medicine – from biophysics to the clinic: Webinar with Marvin Edeas and Stephan Nussberger, May 12, 9:30 a.m. - 12:00 p.m.

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5/11/25

August 2025

Nanodiag BW retreat 2025 - Sankt Märgen

News
8/19/25

October 2025

Dynamic coupling between Tom22 motions and Tom40 pore dynamics modulates ion transport in the mitochondrial TOM complex. Acharya et al. ACS J. Chem. Inf. Model. 65: 12475-12488 (2025)

News
10/21/25

August 2020

Posterpreis des 9. Internationalen Geminivirus Symposiums in Davis, USA (2019) für Andrea Happle

News
8/11/20

Kleinow et al. (2020) Frontiers in Plant Science

News
8/11/20

October 2018

Jeske H. 2018, Virology

News
10/5/18

Wenz et al. 2018, Nanoscale

News
10/5/18

Wege & Lomonossoff 2018, Methods in Molecular Biology

News
10/3/18

February 2022

Invited Lecture Univ. Madrid - Re-shaping the future of nano: Synthetic plant virology for particle design and biosensor enhancement

News
2/18/22

August 2022

Welden et al. (2022). Towards Multi‐Analyte Detection: Field‐Effect Capacitors with TMV Bioparticles as Enzyme Nanocarriers

News
8/2/22

Paiva et al. (2022). Enzymatic activity of individual bioelectrocatalytic viral nanoparticles: AFM-SECM studies enabled by tobacco mosaic virus scaffolds.

News
8/2/22

June 2022

International Black Forest Symposium 22-24 June 2022: "Viral Findings of Curious Scientific Friends" - based on the grounds of Holger Jeske

News
6/28/22

February 2023

University of St. Andrews - Synthetic Plant Virology

News
2/15/23

December 2019

Plant virus-based materials for biomedical applications: Trends and prospects

News
12/19/19

Gips-Schüle-Nachwuchspreis 2019 (2. Platz) für Dr. Claudia Koch

News
12/19/19

August 2023

Geiger et al. (2023), Virology

News
8/8/23

Tobamoviral nanocarriers for synthetic enzyme systems

News
8/8/23

4th European Biosensor Symposium 2023: Keynote Lecture C. Wege

News
8/30/23

November 2023

Grübel et al. (2023): All-soft hydrogel biosensors functionalized by help of plant viral enzyme nanocarriers

News
11/8/23

May 2024

Getting Hold of the Tobamovirus Particle - Why and How?

News
5/30/24

February 2019

EraNet Network meeting in Barcelona February 26- March 01, 2019

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2/26/19

March 2019

Meeting of the German Neuroscience Society Göttingen March 20 - 23, 2019

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3/20/19

Bonn Brain 3 meeting March 25-27, 2019

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3/25/19

Minerva Symposium Regensburg in Juni 2019

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3/11/19

Mediterranean Neuroscience Society Meeting Marrakech 23-27.06.2019

News
3/6/19

Münster A, Huster J, Sommer S, Traxler C, Votteler A, Hauber W (2024) Enhanced Risky Choice in Male Rats Elicited by the Acute Pharmacological Stressor Yohimbine Involves Prefrontal Dopamine D1 Receptor Activation.

News
3/6/24

July 2023

S. Deiana, W. Hauber, A. Muenster, S. Sommer, B. Ferger, A. Marti, B. Schmid, C. Dorner-Ciossek, H. Rosenbrock; Eur J Pharmacol 2022 "Pro-cognitive effects of the GlyT1 inhibitor Bitopertin in rodents"

News
7/20/23

Münster A et al. Neuropharmacology 2022 "Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions"

News
7/20/23

December 2022

We received funding from the German research foundation (DFG) within the DFG research unit FOR 5434 “Information abstraction during sleep”.

News
12/5/22

October 2024

DFG-ANR Grant funded.

News
10/14/24

December 2019

Bridging biomedical and nanotechnology applications - Network in Physical Virology, Bilbao 2019: Plenary Talk

News
12/19/19

SFB1214, University of Konstanz: Anisotropic Particles as Building Blocks - TMV meets physics and chemistry

News
12/19/19

From stars to stripes: RNA-directed shaping of plant viral protein templates - structural synthetic virology for smart biohybrid nanostructures (2019). Wege & Koch, WIREs Nanomed Nanobiotechnol e1591.

News
12/19/19

February 2020

Wiley Interdisciplinary Reviews: Nanomed & Nanobiotechnol 12, 2 (2020), e1591: Wege &Koch, Structural Synthetic Virology for Smart Biohybrid Nanostructures

News
2/27/20

September 2020

FENS Forum 2020

News
9/7/20

December 2020

Stellenausschreibung für eine studentische oder wissenschaftliche Hilfskraft (m/w/d)

News
12/11/20

July 2023

Sommer S, Münster A, Fehrentz JA, Hauber W, 2022, Int J Neuropsychopharmacol., "Effects of Motivational Downshifts on Specific Pavlovian-Instrumental Transfer in Rats."

News
7/20/23

February 2021

Prof. Ehrlich appointed as Associate Editor for the journal “Neurobiology of Learning and Memory”

News
2/8/21

June 2021

Intercalated amygdala clusters orchestrate a switch in fear state. Hagihara et al. (2021) Nature

News
6/24/21

Midbrain dopaminergic inputs gate amygdala intercalated cell clusters by distinct and cooperative mechanisms in male mice. Aksoy-Aksel et al, (2021) Elife

News
6/24/21

July 2021

Forschungsprojekt zur Rolle des Orbitofrontalen Cortex bei Lernvorgängen von der DFG im Normalverfahren gefördert.

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7/5/21

October 2021

DFG funds research project on molecular mechanisms of synaptic plasticity

News
10/6/21

News

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10/6/21

July 2023

G. B. Shaw: " There is no sincerer love than the love of food”

News
7/20/23

August 2024

Ingrid Ehrlich was appointed as „Vertrauensdozentin“ of the German National Academic Scholarship Foundation.

News
8/14/24

June 2025

Alexandra Münster completed her Ph.D. on “Neurobiological studies on the role of the orbitofrontal cortex in action control“. Congratulations!

News
6/4/25

July 2025

MARSS Conference 2025 - USA

News
7/20/25

April 2018

Brauner et al., 2018, The Plant Journal

News
4/20/18

May 2018

Hörmiller et al., 2016, Plant Cell Environ

News
5/28/18

July 2018

Hoermiller et al., 2018, Planta

News
7/19/18

October 2018

Mishra et al., 2018, Photosyn Res

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10/11/18

Birami et al., 2018, Frontiers in Forests and Global Change

News
10/31/18

January 2019

Küstner et al., 2019, npj Systems Biology and Applications

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1/28/19

August 2019

Küstner et al., 2019, Plant Journal

News
8/30/19

Fürtauer et al., 2019, Plant Journal

News
8/30/19

October 2019

Hell et al., 2019, Frontiers in Plant Science

News
10/23/19

January 2020

Helisch et al., 2020, Space Research

News
1/24/20

February 2020

Fürtauer et al., 2019, Plant J - Outstanding Paper Award

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2/26/20

July 2020

Krämer et al., 2020, paropt: Parameter Optimizing of ODE-Systems

News
7/7/20

March 2021

Roth-Nebelsick et al., 2021, Structure and functional anatomy of the gas exchange apparatus of leafless orchids: evidence for a control mechanism?

News
3/25/21

Krämer et al., 2022, Acclimation to elevated CO2 affects the C/N balance by reducing de novo N-assimilation

News
3/10/22

July 2022

Krämer et al., 2022, Interaction of Nitrate Assimilation and Photorespiration at Elevated CO2

News
7/26/22

August 2024

Friedrichs et al., 2024, Flux Calculation for Primary Metabolism Reveals Changes in Allocation of Nitrogen to Different Amino Acid Families When Photorespiratory Activity Changes

News
8/21/24

December 2025

Shuo Wang honored with the Bürkert University Prize for her dissertation - Congratulations from the Biophysics Department

News
12/1/25

January 2026

The Biophysics Department congratulates Prof. Sauer (EEP) and Prof. Birke (IPV) for the inauguration of their new WAVE-H2 platform.

News
1/23/26

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