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Institut für Biomaterialien und biomolekulare Systeme

Abteilung Biophysik

News

A synthetic cell microreactor with two types of interacting dynamic DNA-based pores. Sisi Fan et al. Nature Chemistry, doi:10.1038/s41557-026-02124-7 (2026)

A programmable DNA origami nanosyringe for directed membrane translocation. Longjiang Ding et al. Nature Nanotechnology, accepted (2026)

Is TOM sensitive to mechanical cues? See review by Nussberger et al. in Adv. Exp. Med. Biol. pp. 1–28, ISBN 978-3-032-26628-6, in press (2026)

The Biophysics Department congratulates Prof. Sauer (EEP) and Prof. Birke (IPV) for the inauguration of their new WAVE-H2 platform.

Shuo Wang honored with the Bürkert University Prize for her dissertation - Congratulations from the Biophysics Department

Dynamic coupling between Tom22 motions and Tom40 pore dynamics modulates ion transport in the mitochondrial TOM complex. Acharya et al. ACS J. Chem. Inf. Model. 65: 12475-12488 (2025)

Nanodiag BW retreat 2025 - Sankt Märgen

Translational medicine – from biophysics to the clinic: Webinar with Marvin Edeas and Stephan Nussberger, May 12, 9:30 a.m. - 12:00 p.m.

Morphology remodeling and membrane channel formation in synthetic cells via reconfigurable DNA nanorafts. Fan et al. Nature Materials 24: 278-286 (2025)

3D DNA origami pincers that multitask on giant unilamellar vesicles. Zhan et al. Science Advances 10: eadn8903 (2024)

Single-molecule imaging of TOM activity on Biochemical Society Transactions cover

New insights into the structure and dynamics of the TOM complex in mitochondria. Nussberger et al. Biochem. Soc. Trans. 52:911-922 (2024)

TOM core complex cryoEM structure on the cover of Springer Protocols / Methods in Molecular Biology

Tracking the activity and position of mitochondrial beta-barrel proteins. Shuo Wang et al. Methods Mol. Biol. 2778: 221-236 (2024)

TOM holo compex cryoEM structure on PNAS cover

Two conformations of the Tom20 preprotein receptor in the TOM holo complex. Ornelas et al. PNAS 120: e2301447120 (2023)

PhD lecture by Shuo Wang, Monday July 31, 10 am, room 9.120

JoVE Video: Single-molecule imaging of lateral mobility and ion channel activity

ICP and Biophysics group in FORSCHUNG LEBEN 04/23: The use of nanopores to detect potential diseases

Prediction of Por39 membrane porin loops of R. rubrum suitable for CoV2 epitope surface display. Markthaler et al. Comp. Struct. Biotech. J. (2023)

TOM and VDAC in Ionera's channel zoo

Biophysics Group: Open PhD position in single-molecule biochemistry / microscopy

Single-molecule imaging of lateral mobility and ion channel activity in lipid bilayers using TIRF microscopy. Wang et al. JoVE 192: 1-21, doi 10.3791/64970 (2023)

Biophysics Group new member of the BMBF Cluster 4 Future initiative "nanodiag BW"

Bild: Hahn-Schickard

Induction of 2-hydroxycatechol-estrogens O-methylation: A missing puzzle piece in diagnostics and treatment of lung cancer. Musial et al. Redox Biol. 55: 1-13 (2022)

Bachelor- und Masterarbeitsthemen (Nussberger Lab)

Bild: Universität Stuttgart / AG Nussberger / Max Kovalenko

Spatiotemporal stop-and-go dynamics of the mitochondrial TOM core complex correlates with three-state channel activity. Shuo Wang et al. Communications Biology: 5, 1-11 (2022)

Shuo Wang et al. exploit single-molecule measurements to uncover a potentially new mechanosensitive functionality of TOM. Blog post: Nature Portfolio Bioengineering Community (2022)

Electron microscopy-based structure of TOM core complex now also published in the textbook Voet & Voet Biochemistry 4th edition - International adaptation (2021)

Regulation of mitochondrial dynamics in 2-methoxyestradiol-mediated osteosarcoma cell death. Magda Gorska-Ponikowska et al. (2021) Scientific Reports 1-12

In depth interrogation of protein thermal unfolding data with MoltenProt. Kotov et al. (2020) Protein Science doi: 10.1002/pro.3986

The structure of the TOM core complex in the mitochondrial outer membrane. Bausewein et al. (2020) Biological Chemistry

Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery. Biomaterials 219: 119394 (2019), coauthored by Shuo Wang / Biophysics Group

Nitric oxide and its derivatives in the cancer battlefield: Kamm et al. (2019) Nitric Oxide: S1089-8603 (19) 30119-3.

The Art of Sucking Protein-Spaghetti auf der 69. Lindauer Nobelpreisträgertagung

Cryo-EM structure of Neurospora crassa respiratory complex IV: Bausewein et al. (2019) IUCrJ 6: 773-780, coauthored by S. Nussberger / Biophysics group

The adoption of three-dimensional additive manufacturing from biomedical material design to 3D organ printing: Review, coauthored by Shuo Wang; Appl. Sci. (2019)

Methoxyestradiol affects mitochondrial biogenesis in osteosarcoma cancer cells, Gorska et al. Cancer Gen. Proteom. 15: 73-89 (2018)

Biophysikalische Grundlagen der Zellphysiologie - Erste Video-Podcasts für Studierende der Technischen Biologie und Biomedizintechnik online

Neues Drittmittelprojekt (Nussberger Lab)

Bild: Universität Stuttgart / AG Nussberger / Max Kovalenko

Cryo-EM Struktur von TOM, Bausewein et al (2017) Cell 170: 693-700

Pore proteins: about holes in mitochondria, Nussberger labor&more 1.10: 30-33 (2010)

Reconstitution of the membrane protein OmpF into biomimetic block copolymer-phospholipid hybrid membranes. Bieligmeyer et al. Beilstein J. Nanotechnol. 7: 881-892 (2016)

New third-party funded project (Nussberger Lab): De novo design of biological nanopores for biosensors

Der Spaghetti-Effekt

Bild: Stock/Melica

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